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July 18, 2024 7 min read
Aging is a complex process involving several critical signaling pathways, including ERK, AMPK, and mTORC1. Inflammation is a central hallmark of aging, contributing to various age-related diseases and conditions. This study focuses on IL-11, a pro-inflammatory cytokine from the IL-6 family, and its impact on healthspan and lifespan. Researchers hypothesized that inhibiting IL-11 could mitigate age-associated pathologies and extend lifespan.
Chronic sterile inflammation is increasingly recognized as a key factor in aging. Aging is associated with a dysfunctional immune system, characterized by immunosenescence and thymic involution, alongside inappropriate activation of innate immune genes such as IL-6. Pro-inflammatory signaling factors like NF-κB and JAK–STAT3 are specifically implicated in aging. Inhibiting these pathways has shown potential in alleviating age-related dysfunction.
IL-11 plays a significant role in age-associated pathologies. It can activate both the ERK–mTORC1 and JAK–STAT3 pathways, contributing to metabolic decline, multi-morbidity, and frailty in old age. Researchers found that IL-11 is upregulated in older individuals, further supporting its role in senescence, a hallmark of aging.
IL-11 affects multiple aging pathways, including ERK, AMPK, mTOR, and JAK–STAT3. The study shows that inhibiting IL-11 has pleiotropic benefits, modulating these pathways and reducing age-associated pathologies.
Inhibition of IL-11 in old mice resulted in metabolic benefits similar to those seen in young mice with WAT-specific deletion of Raptor. This includes lower body weight, reduced fat mass, and improved glucose tolerance and insulin sensitivity. IL-11 inhibition also preserved mitochondrial function and prevented the age-related decline in telomere length and mitochondrial DNA content.
IL-11 is linked with senescence, contributing to tissue fibrosis and other aging-related issues. Inhibiting IL-11 reduced senescence markers in various tissues, improved muscle strength, and reduced frailty. These benefits were apparent even in young mice, suggesting that IL-11 has a significant impact on metabolic health and tissue integrity.
Inhibition of IL-11 significantly extended the lifespan of both male and female mice. The magnitude of lifespan extension remains to be fully determined, but current data suggest a more than 20% increase in median lifespan. Anti-IL-11 therapy was effective when administered in late life, indicating its potential for extending lifespan even when started later in life.
Cancer is a common cause of death in old mice. The study found that inhibition of IL-11 significantly reduced the incidence of age-related cancers. This supports the notion that IL-11 plays a role in tumorigenesis and tumor immune evasion. Clinical trials of anti-IL-11 in combination with immunotherapy to treat cancer are planned.
Given the promising results in mice, IL-11 inhibition is proposed as a potential therapy for age-related diseases in humans. Anti-IL-11 therapies, currently in trials for fibrotic lung disease, may also benefit older adults by reducing inflammation and improving overall health.
This study highlights the potential of IL-11 inhibition as a powerful anti-aging therapy. By reducing chronic inflammation and improving metabolic health, IL-11 inhibitors could enhance both healthspan and lifespan in humans. The therapy's safety profile and ongoing clinical trials suggest it could be a viable option for extending human healthspan and lifespan.
The study demonstrates that IL-11 plays a critical role in age-related pathologies and lifespan. Inhibiting IL-11 has significant benefits for metabolic health, tissue integrity, and longevity. These findings suggest that anti-IL-11 therapy could be a promising approach to extend human healthspan and lifespan, providing a new avenue for anti-aging interventions.
Discover how inhibiting IL-11 can extend both healthspan and lifespan. IL-11, a pro-inflammatory cytokine, impacts age-related diseases and metabolic decline. Blocking IL-11 improves metabolism, reduces frailty, and significantly extends lifespan in mice. This study reveals the potential of IL-11 inhibition as a powerful anti-aging therapy, enhancing healthspan and lifespan by reducing chronic inflammation and improving metabolic health. With ongoing clinical trials, IL-11 inhibitors could become a viable option for extending human healthspan and lifespan, offering a promising future for anti-aging interventions.
In the meantime, here are a few proven, commercially-available products for improving wellness and increasing lifespan.
Recent research highlights several innovative therapies that show promise in enhancing wellness and extending lifespan. Cryotherapy, which involves exposing the body to extremely cold temperatures, is lauded for its ability to treat pain and inflammation, potentially improving overall health and longevity. Vibration plates, such as those available from LifetimeVibe and VibePlate, use micro-vibrations to stimulate muscles, enhance circulation, and aid in calorie burning, contributing to better physical health. Red light therapy (RLT) is another emerging treatment, showing efficacy in reducing wrinkles, redness, acne, and scars, making it a valuable tool in the anti-aging arsenal.
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Ageing
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